Attenuation of Herpes Simplex Virus Neurovirulence with Picornavirus cis -Acting Genetic Elements
نویسندگان
چکیده
منابع مشابه
Attenuation of herpes simplex virus neurovirulence with picornavirus cis-acting genetic elements.
Viral pathogenesis depends on a suitable milieu in target host cells permitting viral gene expression, propagation, and spread. In many instances, viral genomes can be manipulated to select for propagation in certain tissues or cell types. This has been achieved for the neurotropic poliovirus (PV) by exchange of the internal ribosomal entry site (IRES), which is responsible for translation of t...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2007
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.00714-06